The gathering of Euphorbia seeds poses a challenge for many horticulturalists as the fruit capsules burst open when ripe and the seeds are released explosively and scattered over long distances. To prevent loss of seeds, horticulturalists either place nylon stockings around the ripe fruit capsules or they apply a thin layer of glue to the capsule. The collected seeds are sown in pots or trays that contain a combination of fine to medium grain sand and loam soil. It is recommended that the soil should be sterilized in an oven or autoclave for 20 minutes or pre-treated with fungicides to prevent infections. The seeds are sown by pressing them lightly into the soil and covering them with a thin layer of sand, keeping the soil damp but not wet at a temperature of 27–30°C.

The plants can also be propagated by stem cuttings. Cuttings should be dipped in rooting powder and planted in a pot. Cuttings can also be placed in jar filled with water to promote rooting. Water should be changed daily to prevent contamination by excess latex exuding from the wound.