Euphorbia virosa can be propagated from seeds and also from cuttings. Seed must be collected when the seed capsules are ripe but before they are quite dry, because they then burst explosively scattering the seeds far away from the plant. The capsules should be placed in a paper bag once collected and placed in a dry warm area to dry out. Once the seeds are all released from the capsules they should be sown into a tray with a sandy, well-drained medium. The seeds will most likely germinate after 14 days in temperatures ranging from approximately 18-22°C. Protective gloves and goggles should be worn during seed collection to prevent contact with the sharp thorns but especially to prevent possible blindness and skin cancer caused by the milky sap.

The species can also be propagated from cuttings. Here again, extreme caution must be exercised and goggles and gloves must be worn. The surface of the cutting wound should be left to dry out for at least 2 to 3 weeks before planting. The cuttings should be planted in a well-drained rooting medium and placed in a well-ventilated environment. Overwatering should be avoided, as this may cause stem rot.