Pteronia paniculata grows extremely well in dry and hot conditions and grows rapidly under favourable conditions. Sandy-loam soil with coarse sand particles, consisting of a pH of 5.5, is ideal for growing P. paniculata.

At the Karoo Desert National Botanical Garden, P. paniculata is propagated through seed sowing and it does extremely well. Seeds are collected in autumn. When the flowerheads are dry, they are grinded to free the tiny seeds, stored and sown in summer. Use a mixture of sand and sifted potting soil at a ratio of 50:50. Prepare germination trays with good drainage, place coarse bark chips or any coarse particles that will encourage drainage, in the trays. Sow gum-bush seeds on the surface of the soil medium and cover them with fine soil to avoid being washed away during watering. Do not bury the seeds, as they are tiny. Water the seed trays with a fine spray, or mist sprayer, which is preferred for watering tiny seeds. Place trays in a semi-shaded area and keep them moist all the time and not damp, until germination takes place. Germination will take place in about 2 weeks on average.

When seeds have germinated, reduce watering and allow air circulation through the soil. Transplant the seedlings about 3 months after germination. Use sandy loam soil for transplanting, with the addition of organic fertilizers or well-decomposed compost. Do not apply too much of the nutrient supplements as it may pose a disease threat to the plant. Handle roots carefully when transplanting and keep seedlings in a semi-shaded area after transplanting, until they are well adapted to their new conditions. After adapting to new containers, move seedlings to a full sun area before planting into an open space in the garden.

Propagation by cuttings has not being tried on this species at the Karoo Desert NBG. However, one of the relatives, P. aspera is being easily propagated by cuttings at Kirstenbosch National Botanical Garden. Cuttings are done throughout the year. About 30 mm to 60 mm of softwood to semi-hardwood cuttings are made. Make a cutting just underneath the node and dip the cuttings into a rooting hormone. Use coarse river sand as a cutting medium, a ratio of 70% river sand and 30% peat or fine potting mix will support the growing of cuttings. Place cuttings in a glasshouse or misting unit with a heated bench. When cuttings have rooted, apply the same procedures as those described above for the transplanting of seedlings.