Lampranthus affinis is easy to grow and flowers profusely in late spring. It can be grown in shady situations, but prefers high light intensity, e.g. open shade (an area that does not necessarily receive direct sun but is open to the sky) or bright shade. It can also be grown in semi-shade or full sun. It thrives out of doors but needs protection from frost. Grow in sandy soil, adding ample bone meal and compost. Water during winter, spring and summer. The plants have a life span of 4 to 8 years.

It can be grown in dry fynbos and succulent karoo gardens together with other succulents such as Cotyledon orbiculata, Aloe microstigma, A. mitriformis, Crassula tetragona, C. ovata, C. arborescens, C. perforata, C. rubricaulis and C. rupestris. It grows well in containers, and is also suitable for a shady stoep (verandah), or on the shady side of rockeries. The caterpillars of the tiger moth can be troublesome but are easily removed by hand. The caterpillars could be fed to local pets such as tilapia, goldfish or omnivorous tropical fish.

It is easily grown from cuttings, rooted in sand during the warmer months of the year and will flower profusely by the next season. Take cuttings of about 6-12 cm in length, remove the lower leaves and plant the lower half in a sandy medium, keeping it moist. Rooting should occur within 3 weeks and then transfer the cuttings directly to wherever they are needed. Sow seed in shallow trays in the standard way and cover lightly with a layer of sand (1-2 mm). Germination occurs within 4 weeks. Plant the young seedlings as soon as they are large enough to handle.